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Medication that inhibit CYP2D6 exercise, for example paroxetine and quinidine, may trigger decreased clearance of oxycodone which could lead on to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Ritonavir or lopinavir/ritonavir significantl